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The lively thread on @meekmeek2u_’s May-08 post quickly became a peer-to-peer master-class on how two superficially similar conditions diverge at the molecular level. Patients and clinicians compared imaging findings, with several users posting ultrasound clips that show the honey-comb fat pattern typical of lipedema versus the dermal back-flow channels of lymphedema. A vascular surgeon weighed in on why combined lipolymphatic disease demands staged debulking and lymph-venous bypass. Genetics also surfaced: commenters cited the AKT1 and PIK3CA variants linked to over-growth syndromes and asked whether targeted PI3K-inhibitors entering phase-II trials could translate to lipedema. The consensus? Differential diagnosis still hinges on clinical acumen, but 2025’s crop of circulating micro-RNA panels—and the newly published single-cell lymphatic endothelium atlas—promise faster, gene-guided triage. Take-home for practitioners: integrate duplex mapping with emerging serum biomarkers; for patients: insist on a multidisciplinary plan that addresses adipose-driven pain and lymphatic mechanics. instagram.com
May 30 2025 — la discussione potrebbe continuare visita la pagina INSTAGRAM
