Posted 29 May 2025, this thread drew over 60 comments within a day. The original poster (OP) described dramatic overnight limb deflation while on high-dose amoxicillin for a dental abscess, followed by rebound edema and sweats. Infectious-disease specialists explained that systemic infection can transiently shift interstitial oncotic pressure, whereas lymphatic injury limits rebound drainage once antibiotics stop. Experienced patients stressed daily temperature checks and prophylactic penicillin for recurrent cellulitis. Surgeons advised urgent Doppler if swelling stays asymmetric to exclude DVT before resuming pneumatic pumps.
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