Menopause represents a critical point in the development of lipedema, a condition characterized by an abnormal accumulation of adipose tissue, mainly in the legs and arms. During menopause, hormonal changes, especially the reduction of estrogen, can alter the balance of estrogen receptors in the body. This imbalance can negatively affect the function of adipose tissue, contributing to the onset and aggravation of lipedema.
In addition, the alteration of intracrine estrogen metabolism, i.e. the production and action of estrogen within fat cells, can further aggravate adipose tissue dysfunction. These hormonal and metabolic changes during menopause can then act as triggers or exacerbators for lipedema.
Understanding the role of menopause in this context is critical to developing targeted therapeutic strategies. Interventions that aim to restore hormonal balance and improve adipose tissue function could be effective in treating lipedema, especially in postmenopausal women.
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The article was published on PubMed on 2025-08-14 12:00:00
the original title is Menopause as a Critical Turning Point in Lipedema: The Estrogen Receptor Imbalance, Intracrine Estrogen, and Adipose Tissue Dysfunction Model
The authors of the article as they appear indicated are: Diogo Pinto da Costa Viana and others
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